ERC Advanced Grant to Ralph Müller
Professor Ralph Müller, Head Laboratory for Bone Biomechanics, has received an Advanced Grant of the European Research Council (ERC) for his MechAGE project. With that grant, the ERC is financing Müller‘s research on in vivo single-cell mechanomics of bone adaptation and regeneration in the aging mouse. The funding is 2.5 Million Euro over the next five years.
MechAGE aims to investigate how mechanical vibrations influence bone development, adaptation and regeneration, which cell types are involved in these processes and how these cells react to age-related change. Specifically, Müller wants to use genome sequencing of single cells to understand how molecular ageing processes under mechanical loads affect bone remodeling. In the future, this understanding may facilitate targeted exercise programs within the context of personalized medicine to prevent osteoporosis-related bone fractures or heal them more quickly.