Multiscale Mechanobiology
The Multiscale Mechanobiology team investigates how mechanical forces shape biological systems across molecular, cellular, tissue, and organ levels. By integrating experimental, computational, and clinical approaches, we tackle challenges in fracture healing, ageing, and drug response, advancing bone health research. Our expertise lies in bridging scales and methods to enable innovative solutions for precision medicine and regenerative therapies.
Our Goal
We aim to develop and validate clinical and preclinical in silico models through in vitro organotypic bone systems and in vivo data analysis. Additionally, we strive to create advanced in vitro models that closely resemble human pathophysiology. These models not only deepen our understanding of bone mechanobiology but also align with the 3R principles (Refine, Reduce, Replace) to minimize the reliance on animal models. This comprehensive approach accelerates patient-specific treatment development and drives advances in disease modeling, regenerative medicine, and precision therapies. By unifying experimental and computational workflows, we address critical challenges in bone health, including ageing and skeletal disorders, to drive innovation in precision medicine.
Our Expertise
Our team combines expertise in bone biology, advanced numerical and computational methods, and experimental approaches to develop integrative models of bone health. We create in silico models of bone healing, remodeling, and mechanobiology, complemented by in vitro organotypic bone models and analyses of in vivo patient data using tools like micro-computed tomography (micro-CT). These efforts uncover multiscale insights and ensure clinical relevance through model validation and parameterization. With a diverse background in engineering and science, and collaborations across preclinical and clinical settings, we bridge experimental, computational, and clinical domains to drive advances in precision medicine, disease modeling, and regenerative therapies for bone health.
Principle Investigator
Institut für Biomechanik
Gloriastrasse 37/ 39
8092
Zürich
Switzerland
